承担 的主 要项 目及 成果 |
作为负责人承担项目: (1) 国家自然科学基金青年项目,21708023,蛋白靶向的比率型谷胱甘肽荧光探针构建与亚细胞定量检测研究,25万元,2018.01-2020.12,主持 (2) 中国博士后面上二等资助西部计划项目,2019M653850XB,可逆型谷胱肽荧光探针的细胞器靶向设计与检测研究,8万元,2019.06-2021.5,主持 (3) 陕西省自然科学基础研究计划青年项目,2019JQ-061,基于聚集诱导发光分子的蛋白质特异性标记策略设计与生物应用研究,3万元,2019.01-2020.12,主持 (4) 陕西科技大学博士科研启动金,2017GBJ-04,亚细胞蛋白特异性荧光标记与生物分析应用研究,20万元,主持 论文发表: 发表SCI论文十余篇。 (16) Chao Wang*, Tingting Wang, Min Zhao, Fangfang Dai, Zhuolan Niu, Wenqing Zhang, Yangmin Ma*. A simple chalcone molecular rotor for specific fluorescence imaging of mitochondrial viscosity changes in living cells. Dyes and Pigments, 2021, 194: 109593. (15) Fangfang, Dai; Min, Zhao; Fangzhou, Yang; Tingting, Wang; Chao, Wang*; An ESIPT coupled AIE fluorescent probe for biothiols detection and imaging based on a chalcone fluorophore, Dyes and Pigments, 2020, 183: 108627. (14) Chao Wang, Minjie Jia, Zhe Bai, Midong Shi, Xiangli Chen, Juan Fan, Fangfang Dai*. The separation of isopropyl alcohol from diisopropyl ether system using glycols: Phase equilibrium and rigorous correlation. Journal of Chemical Thermodynamics, 2020, 150. (13) Chao Wang, Xinbo Song, Lingcheng Chen, Yi Xiao*. Specifically and Wash-Free Labeling of SNAP-tag Fused Proteins with a Hybrid Sensor to Monitor Local Micro-Viscosity. Biosensors & Bioelectronics, 2017, 91: 313-320. (12) Chao Wang1, Xinbo Song1, Yi Xiao*. SNAP-tag Based Subcellular Proteins Labeling and Fluorescent Imaging with Naphthalimides. ChemBioChem, 2017, 18(17): 1762-1769. (11) Chao Wang1, Xinbo Song1, Zhuo Han, Xiaoyu Li, Yongping Xu, Yi Xiao*. Monitoring Nitric Oxide in Subcellular Compartments by Hybrid Probe Based on Rhodamine Spirolactam and SNAP-tag. ACS Chemical Biology, 2016, 11(7): 2033-2040. (10) Fu Yang1, Chao Wang1, Lu Wang, Zhiwei Ye, Xinbo Song, Yi Xiao*. Hoechst- Naphthalimide Dyad with Dual Emissions as Specific and Ratiometric Sensor for Nucleus DNA Damage. Chinese Chemical Letters, 2017, 28(10): 2019-2022.(共同第一作者) (9) Xinbo Song1, Chao Wang1, Zhuo Han, Yongping Xu*, Yi Xiao*. Terminal Alkyne Substituted O6-benzylguanine for Versatile and Effective Syntheses of Fluorescent Labels to Genetically Encoded SNAP-tags. RSC Advances, 2015, 5(30): 23646-23649.(共同第一作者) (8) Jianhua Wang1, Yuzheng Zhao1, Chao Wang1, Qian Zhu, Zengmin Du, Aiguo Hu*, Yi Yang*. Organelle-Specific Nitric Oxide Detection in Living Cells via HaloTag Protein Labeling. Plos One, 2015, 10(4): e0123986.(共同第一作者) (7) Xinbo Song, Ning Li, Chao Wang, Yi Xiao*. Targetable and Fixable Rotor for Quantifying Mitochondrial Viscosity of Living Cells by Fluorescence Lifetime Imaging. Journal of Materials Chemistry B, 2017, 5(2): 360-368. (6) Xinbo Song, Hui Bian, Chao Wang, Mingyu Hu, Ning Li, Yi Xiao*. Development and Applications of a Near-Infrared Dye-Benzylguanine Conjugate to Specifically Label SNAP-tagged Proteins. Organic & Biomolecular Chemistry, 2017, 15: 8091-8101. (5) Jingwen Zhang, Chao Wang, Lei Zhang, Huijing Wu, Yi Xiao*, Yufang Xu, Xuhong Qian, Weiping Zhu*. Novel Nonplanar and Rigid Fluorophores with Intensive Emission in Water and the Application in Two-Photon Imaging of Live Cells. RSC Advances, 2016, 6(75): 71624-71627. (4) Xinfu Zhang, Benlei Wang, Chao Wang, Lingcheng Chen, Yi Xiao* Monitoring Lipid Peroxidation within Foam Cells by Lysosome-Targetable and Ratiometric Probe. Analytical Chemistry, 2015, 87(16): 8292-8300. (3) Benlei Wang, Xinfu Zhang, Chao Wang, Lingcheng Chen, Yi Xiao*, Yi Pang*. Bipolar and Fixable Probe Targeting Mitochondria to Trace Local Depolarization via Two-Photon Fluorescence Lifetime Imaging. Analyst, 2015, 140(16): 5488-5494. (2) Xinfu Zhang, Chao Wang, Zhuo Han, Yi Xiao*. A Photostable Near-Infrared Fluorescent Tracker with pH-Independent Specificity to Lysosomes for Long Time and Multicolor Imaging. ACS Applied Materials & Interfaces, 2014, 6(23): 21669-21676. (1) Xinfu Zhang, Chao Wang, Liji Jin, Zhuo Han, Yi Xiao*. Photostable Bipolar Fluorescent Probe for Video Tracking Plasma Membranes Related Cellular Processes. ACS Applied Materials & Interfaces, 2014, 6(15): 12372-12379.
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